ZFIN ID: ZDB-PUB-170214-159
Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes
Tuazon, F.B., Mullins, M.C.
Date: 2015
Source: Seminars in cell & developmental biology   42: 118-33 (Review)
Registered Authors: Mullins, Mary C.
Keywords: BMP, FGF, Gastrulation, Morphogens, Nodal, Wnt
MeSH Terms:
  • Animals
  • Body Patterning*
  • Signal Transduction*
  • Vertebrates/embryology*
  • Vertebrates/metabolism
  • Xenopus/embryology
  • Xenopus/metabolism
  • Zebrafish/embryology
  • Zebrafish/metabolism
PubMed: 26123688 Full text @ Sem. Cell Dev. Biol.
The vertebrate body plan is established through the precise spatiotemporal coordination of morphogen signaling pathways that pattern the anteroposterior (AP) and dorsoventral (DV) axes. Patterning along the AP axis is directed by posteriorizing signals Wnt, fibroblast growth factor (FGF), Nodal, and retinoic acid (RA), while patterning along the DV axis is directed by bone morphogenetic proteins (BMP) ventralizing signals. This review addresses the current understanding of how Wnt, FGF, RA and BMP pattern distinct AP and DV cell fates during early development and how their signaling mechanisms are coordinated to concomitantly pattern AP and DV tissues.