|ZFIN ID: ZDB-PUB-170214-159|
Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes
Tuazon, F.B., Mullins, M.C.
|Source:||Seminars in cell & developmental biology 42: 118-33 (Review)|
|Registered Authors:||Mullins, Mary C.|
|Keywords:||BMP, FGF, Gastrulation, Morphogens, Nodal, Wnt|
|PubMed:||26123688 Full text @ Sem. Cell Dev. Biol.|
Tuazon, F.B., Mullins, M.C. (2015) Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes. Seminars in cell & developmental biology. 42:118-33.
ABSTRACTThe vertebrate body plan is established through the precise spatiotemporal coordination of morphogen signaling pathways that pattern the anteroposterior (AP) and dorsoventral (DV) axes. Patterning along the AP axis is directed by posteriorizing signals Wnt, fibroblast growth factor (FGF), Nodal, and retinoic acid (RA), while patterning along the DV axis is directed by bone morphogenetic proteins (BMP) ventralizing signals. This review addresses the current understanding of how Wnt, FGF, RA and BMP pattern distinct AP and DV cell fates during early development and how their signaling mechanisms are coordinated to concomitantly pattern AP and DV tissues.
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