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ZFIN ID: ZDB-PUB-170120-1
A single identified glomerulus in the zebrafish olfactory bulb carries the high-affinity response to death-associated odor cadaverine
Dieris, M., Ahuja, G., Krishna, V., Korsching, S.I.
Date: 2017
Source: Scientific Reports 7: 40892 (Journal)
Registered Authors: Ahuja, Gaurav, Korsching, Sigrun
Keywords: Neurophysiology, Olfactory bulb
MeSH Terms:
  • Animals
  • Cadaverine/pharmacology*
  • Extracellular Signal-Regulated MAP Kinases/metabolism
  • Immunohistochemistry
  • Microscopy, Fluorescence
  • Odorants/analysis
  • Olfactory Bulb/metabolism*
  • Olfactory Bulb/pathology
  • Olfactory Receptor Neurons/drug effects*
  • Olfactory Receptor Neurons/metabolism
  • Receptors, Odorant/metabolism*
  • Zebrafish/metabolism*
  • Zebrafish Proteins/metabolism*
PubMed: 28102357 Full text @ Sci. Rep.
The death-associated odor cadaverine, generated by bacteria-mediated decarboxylation of lysine, has been described as the principal activator of a particular olfactory receptor in zebrafish, TAAR13c. Low concentrations of cadaverine activated mainly TAAR13c-expressing olfactory sensory neurons, suggesting TAAR13c as an important element of the neuronal processing pathway linking cadaverine stimulation to a strongly aversive innate behavioral response. Here, we characterized the initial steps of this neuronal pathway. First we identified TAAR13c-expressing cells as ciliated neurons, equivalent to the situation for mammalian taar genes, which shows a high degree of conservation despite the large evolutionary distance between teleost fishes and mammals. Next we identified the target area of cadaverine-responsive OSNs in the olfactory bulb. We report that cadaverine dose-dependently activates a group of dorsolateral glomeruli, at the lowest concentration down to a single invariant glomerulus, situated at the medial border of the dorsolateral cluster. This is the first demonstration of a single stereotyped target glomerulus in the fish olfactory system for a non-pheromone odor. A mix of different amines activates many glomeruli within the same dorsolateral cluster, suggesting this area to function as a general amine response region.