PUBLICATION
Toxicity of hemimethyl-substituted cucurbit[7]uril
- Authors
- Yang, X., Zhao, W., Wang, Z., Huang, Y., Lee, S.M., Tao, Z., Wang, R.
- ID
- ZDB-PUB-170114-8
- Date
- 2017
- Source
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 108(Pt B): 510-518 (Journal)
- Registered Authors
- Keywords
- Hemimethyl-substituted cucurbit[7]uril, Macrocyclic molecule, Toxicity, Zebrafish
- MeSH Terms
-
- Animals
- Bridged-Ring Compounds/chemistry*
- Bridged-Ring Compounds/toxicity*
- Cell Line
- Chemical and Drug Induced Liver Injury
- Embryo, Nonmammalian/drug effects
- Heart/drug effects
- Heart/embryology
- Hepatocytes/drug effects
- Humans
- Imidazoles/chemistry*
- Imidazoles/toxicity*
- Models, Molecular
- Stereoisomerism
- Zebrafish/embryology
- PubMed
- 28082230 Full text @ Food Chem. Toxicol.
Citation
Yang, X., Zhao, W., Wang, Z., Huang, Y., Lee, S.M., Tao, Z., Wang, R. (2017) Toxicity of hemimethyl-substituted cucurbit[7]uril. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 108(Pt B):510-518.
Abstract
Hemimethyl-substituted cucurbit[7]uril (HMeCB[7]), a derivative of cucurbit[7]uril (CB[7]) with nearly identical host-guest complexation properties to that of the parent, has significant potential in biomedical sciences due to its superior solubility in water. Its toxicity profile has been investigated in this work, including its developmental and organ-specific toxicities, with both in vivo zebrafish models and a relevant in vitro cellular model. These results demonstrated that HMeCB[7] has negligible developmental toxicity at concentrations up to 3.2 mM and very moderate cardiotoxicity and hepatotoxicity at concentrations of ≥0.8 mM, and is thus generally less toxic than the parent CB[7]. Our results suggest that HMeCB[7] may be a promising candidate of excipient in medicinal and pharmaceutical research fields.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping