PUBLICATION
Infection and immunity against Ichthyophthirius multifiliis in zebrafish (Danio rerio)
- Authors
- von Gersdorff Jørgensen, L.
- ID
- ZDB-PUB-160829-1
- Date
- 2016
- Source
- Fish & shellfish immunology 57: 335-9 (Journal)
- Registered Authors
- Keywords
- Gill infection, Ichthyophthirius multifiliis, Immunity, Zebrafish
- MeSH Terms
-
- Animals
- Ciliophora Infections/immunology
- Ciliophora Infections/mortality
- Ciliophora Infections/parasitology
- Ciliophora Infections/veterinary*
- Coinfection/immunology
- Coinfection/mortality
- Coinfection/parasitology
- Coinfection/veterinary
- Fish Diseases/immunology*
- Fish Diseases/mortality
- Fish Diseases/parasitology
- Gills/parasitology
- Hymenostomatida/physiology*
- Immunity, Innate*
- Zebrafish*
- PubMed
- 27567935 Full text @ Fish Shellfish Immunol.
Citation
von Gersdorff Jørgensen, L. (2016) Infection and immunity against Ichthyophthirius multifiliis in zebrafish (Danio rerio). Fish & shellfish immunology. 57:335-9.
Abstract
Ichthyophthirius multifiliis, causing white spot disease, is a serious pathogen in aquaculture as well as for the ornamental fish industry. In carp, channel catfish and rainbow trout the immune responses against the parasite have been partly elucidated and these species are able to acquire a high level of immunity against the disease. Zebrafish are however, known to be more resilient towards the disease than channel catfish but the pathology and the ability to obtain protection is unknown. In this study a primary infection in the gills of zebrafish was described and the subsequent acquirement of immunity was evaluated. The parasites in the gills induced hyperplasia, an increase of mucus cells, adhesion and shortening of the secondary lamellae, narrowing of water channels and proliferation. The parasite burden was significantly lower in survivor fish and where all naive fish died within 6 days following secondary infection (challenge) only one of the survivor fish died. This study demonstrates that zebrafish are susceptible to I. multifiliis and that gill pathology is similar to what is found in rainbow trout. Furthermore, zebrafish are able to acquire immunity against white spot disease and may therefore be a suitable model organism to study innate and protective immunology and host/parasite interactions during I. multifiliis infections.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping