ZFIN ID: ZDB-PUB-160531-2
Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior
Yabuki, Y., Koide, T., Miyasaka, N., Wakisaka, N., Masuda, M., Ohkura, M., Nakai, J., Tsuge, K., Tsuchiya, S., Sugimoto, Y., Yoshihara, Y.
Date: 2016
Source: Nature Neuroscience   19(7): 897-904 (Journal)
Registered Authors: Miyasaka, Nobuhiko, Sugimoto, Yukihiko, Tsuchiya, Soken, Yoshihara, Yoshihiro
Keywords: Motivation, Olfactory receptors, Pheromone
MeSH Terms:
  • Animals
  • Courtship
  • Dinoprost/metabolism
  • Olfactory Bulb/drug effects
  • Olfactory Bulb/metabolism*
  • Olfactory Receptor Neurons/metabolism*
  • Pheromones/metabolism
  • Receptors, Odorant/metabolism*
  • Receptors, Prostaglandin/metabolism*
  • Reproduction/physiology
  • Sexual Behavior, Animal/physiology
  • Smell/physiology*
  • Zebrafish
PubMed: 27239939 Full text @ Nat. Neurosci.
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ABSTRACT
Pheromones play vital roles in various organisms for survival and reproduction in various organisms. In many fishes, prostaglandin F2α acts not only as a female reproductive hormone, facilitating ovulation and spawning, but also as a sex pheromone inducing male reproductive behaviors. Here, we unravel the molecular and neural circuit mechanisms underlying the pheromonal action of prostaglandin F2α in zebrafish. Prostaglandin F2α specifically activates two olfactory receptors with different sensitivities and expression in distinct populations of ciliated olfactory sensory neurons. Pheromone information is then transmitted to two ventromedial glomeruli in the olfactory bulb and further to four regions in higher olfactory centers. Mutant male zebrafish deficient in the high-affinity receptor exhibit loss of attractive response to prostaglandin F2α and impairment of courtship behaviors toward female fish. These findings demonstrate the functional significance and activation of selective neural circuitry for the sex pheromone prostaglandin F2α and its cognate olfactory receptor in fish reproductive behavior.
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