PUBLICATION

The Contributions of the Ribosome Biogenesis Protein Utp5/WDR43 to Craniofacial Development

Authors
Sondalle, S.B., Baserga, S.J., Yelick, P.C.
ID
ZDB-PUB-160526-4
Date
2016
Source
Journal of dental research   95(11): 1214-20 (Review)
Registered Authors
Yelick, Pamela C.
Keywords
cell biology, craniofacial anomalies, craniofacial biology/genetics, developmental biology, genetics, zebrafish
MeSH Terms
  • Animals
  • Craniofacial Abnormalities/genetics*
  • Facial Bones/growth & development*
  • Humans
  • Nuclear Proteins/genetics
  • Nuclear Proteins/physiology
  • Ribosomal Proteins/genetics
  • Ribosomal Proteins/physiology*
  • Ribosomes/metabolism
  • Ribosomes/physiology
  • Skull/growth & development*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/physiology
PubMed
27221611 Full text @ J. Dent. Res.
Abstract
Fairly recently, it was recognized that human ribosomopathies-developmental defects caused by mutations in ribosome biogenesis proteins-can exhibit tissue-specific defects rather than the expected global defects. This apparent anomaly-that seemingly ubiquitously expressed and required ribosomal proteins can have distinct functions in cell and tissue differentiation-has spurred new areas of research focused on better understanding translational mechanisms, biogenesis, and function in diverse cell types. This renewed appreciation for, and need to better understand, roles for ribosomal proteins in human development and disease has identified surprising similarities and differences in a variety of human ribosomopathies. Here, we discuss ribosomal protein functions in health and disease, focusing on the ribosome biogenesis protein Utp5/WDR43. New and exciting research in this field is anticipated to provide insight into a variety of previously understudied craniofacial dysostoses and result in significantly improved knowledge and understanding of roles for translational machinery in human craniofacial development and disease.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping