PUBLICATION
Leader Cells Define Directionality of Trunk, but Not Cranial, Neural Crest Cell Migration
- Authors
- Richardson, J., Gauert, A., Briones Montecinos, L., Fanlo, L., Alhashem, Z.M., Assar, R., Marti, E., Kabla, A., Härtel, S., Linker, C.
- ID
- ZDB-PUB-160524-6
- Date
- 2016
- Source
- Cell Reports 15(9): 2076-88 (Journal)
- Registered Authors
- Linker, Claudia
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Communication
- Cell Division
- Cell Movement*
- Cell Shape
- Chickens
- Neural Crest/cytology*
- Skull/cytology*
- Torso/physiology*
- Xenopus laevis
- Zebrafish
- PubMed
- 27210753 Full text @ Cell Rep.
Citation
Richardson, J., Gauert, A., Briones Montecinos, L., Fanlo, L., Alhashem, Z.M., Assar, R., Marti, E., Kabla, A., Härtel, S., Linker, C. (2016) Leader Cells Define Directionality of Trunk, but Not Cranial, Neural Crest Cell Migration. Cell Reports. 15(9):2076-88.
Abstract
Collective cell migration is fundamental for life and a hallmark of cancer. Neural crest (NC) cells migrate collectively, but the mechanisms governing this process remain controversial. Previous analyses in Xenopus indicate that cranial NC (CNC) cells are a homogeneous population relying on cell-cell interactions for directional migration, while chick embryo analyses suggest a heterogeneous population with leader cells instructing directionality. Our data in chick and zebrafish embryos show that CNC cells do not require leader cells for migration and all cells present similar migratory capacities. In contrast, laser ablation of trunk NC (TNC) cells shows that leader cells direct movement and cell-cell contacts are required for migration. Moreover, leader and follower identities are acquired before the initiation of migration and remain fixed thereafter. Thus, two distinct mechanisms establish the directionality of CNC cells and TNC cells. This implies the existence of multiple molecular mechanisms for collective cell migration.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping