PUBLICATION
Xiphophorus and Medaka Cancer Models
- Authors
- Schartl, M., Walter, R.B.
- ID
- ZDB-PUB-160512-9
- Date
- 2016
- Source
- Advances in experimental medicine and biology 916: 531-52 (Chapter)
- Registered Authors
- Schartl, Manfred
- Keywords
- Hereditary cancer, Medaka, Melanoma, Oncogene, Signal transduction, Transgenic, Tumor suppressor gene, UV, Xiphophorus
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Carcinogens/toxicity
- Cyprinodontiformes
- Disease Models, Animal*
- Genes, Tumor Suppressor
- Neoplasms/chemically induced
- Neoplasms/genetics
- Neoplasms/pathology*
- Oncogenes
- Zebrafish
- PubMed
- 27165369 Full text @ Adv. Exp. Med. Biol.
Citation
Schartl, M., Walter, R.B. (2016) Xiphophorus and Medaka Cancer Models. Advances in experimental medicine and biology. 916:531-52.
Abstract
Besides recently developed zebrafish cancer models, other fish species have been employed for many years as cancer models in laboratory studies. Two models, namely in Xiphophorus and medaka have proven useful in providing important clues to cancer etiology. Medaka is a complementary model to zebrafish in many areas of research since it offers similar resources and experimental tools. Xiphophorus provides the advantages of a natural ("evolutionary mutant") model with established genetics. Xiphophorus hybrids can develop spontaneous and radiation or carcinogen induced cancers. This chapter describes the tumor models in both species, which mainly focus on melanoma, and summarizes the main findings and future research directions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping