PUBLICATION
Uncharted Waters: Zebrafish Cancer Models Navigate a Course for Oncogene Discovery
- Authors
- Ceol, C.J., Houvras, Y.
- ID
- ZDB-PUB-160512-31
- Date
- 2016
- Source
- Advances in experimental medicine and biology 916: 3-19 (Chapter)
- Registered Authors
- Ceol, Craig, Houvras, Yariv
- Keywords
- BRAF, Cancer, Ras, Transgenic, Zebrafish, p53
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Neoplasms/genetics*
- Oncogenes*
- Zebrafish
- PubMed
- 27165347 Full text @ Adv. Exp. Med. Biol.
Citation
Ceol, C.J., Houvras, Y. (2016) Uncharted Waters: Zebrafish Cancer Models Navigate a Course for Oncogene Discovery. Advances in experimental medicine and biology. 916:3-19.
Abstract
Over a decade has elapsed since the first genetically-engineered zebrafish cancer model was described. During this time remarkable progress has been made. Sophisticated genetic tools have been built to generate oncogene expressing cancers and characterize multiple models of solid and blood tumors. These models have led to unique insights into mechanisms of tumor initiation and progression. New drug targets have been identified, particularly through the functional analysis of cancer genomes. Now in the second decade, zebrafish cancer models are poised for even faster growth as they are used in high-throughput genetic analyses to elucidate key mechanisms underlying critical cancer phenotypes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping