PUBLICATION
The Effect of Chronic Arsenic Exposure in Zebrafish
- Authors
- Hallauer, J., Geng, X., Yang, H.C., Shen, J., Tsai, K.J., Liu, Z.
- ID
- ZDB-PUB-160504-2
- Date
- 2016
- Source
- Zebrafish 13(5): 405-12 (Journal)
- Registered Authors
- Liu, Zijuan
- Keywords
- none
- MeSH Terms
-
- Animals
- Antioxidants/metabolism
- Arsenic/toxicity*
- Environmental Exposure*
- Heart/drug effects*
- Heart/growth & development
- Models, Animal
- Nervous System/drug effects*
- Nervous System/growth & development
- Oxidative Stress
- Water Pollutants, Chemical/toxicity*
- Zebrafish/metabolism*
- PubMed
- 27140519 Full text @ Zebrafish
Citation
Hallauer, J., Geng, X., Yang, H.C., Shen, J., Tsai, K.J., Liu, Z. (2016) The Effect of Chronic Arsenic Exposure in Zebrafish. Zebrafish. 13(5):405-12.
Abstract
Arsenic is a prevalent environmental toxin and a Group one human carcinogenic agent. Chronic arsenic exposure has been associated with many human diseases. The aim of this study is to evaluate zebrafish as an animal model to assess arsenic toxicity in elevated long-term arsenic exposure. With prolonged exposure (6 months) to various concentrations of arsenic from 50 ppb to 300 ppb, effects of arsenic accumulation in zebrafish tissues, and phenotypes were investigated. Results showed that there are no significant changes of arsenic retention in zebrafish tissues, and zebrafish did not exhibit any visible tumor formation under arsenic exposure conditions. However, the zebrafish demonstrate a dysfunction in their neurological system, which is reflected by a reduction of locomotive activity. Moreover, elevated levels of the superoxide dismutase (SOD2) protein were detected in the eye and liver, suggesting increased oxidative stress. In addition, the progenies of arsenic-treated parents displayed a smaller biomass (four-fold reduction in body weight) compared with those from their parental controls. This result indicates that arsenic may induce genetic or epigenetic changes that are then passed on to the next generation. Overall, this study demonstrates that zebrafish is a convenient vertebrate model with advantages in the evaluation of arsenic-associated neurological disorders as well as its influences on the offspring.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping