PUBLICATION
Zebrafish (Danio rerio) embryo as a platform for the identification of novel angiogenesis inhibitors of retinal vascular diseases
- Authors
- Rezzola, S., Paganini, G., Semeraro, F., Presta, M., Tobia, C.
- ID
- ZDB-PUB-160420-12
- Date
- 2016
- Source
- Biochimica et biophysica acta. Molecular basis of disease 1862(7): 1291-6 (Review)
- Registered Authors
- Presta, Marco, Tobia, Chiara
- Keywords
- Angiogenesis, Angiogenesis inhibitors, Embryonic development, Vascular retina diseases, Zebrafish
- MeSH Terms
-
- Angiogenesis Inhibitors/pharmacology*
- Angiogenesis Inhibitors/therapeutic use
- Animals
- Disease Models, Animal
- Drug Evaluation, Preclinical/methods*
- Humans
- Neovascularization, Pathologic/drug therapy*
- Neovascularization, Pathologic/pathology
- Retina/drug effects*
- Retina/pathology
- Retinal Neovascularization/drug therapy*
- Retinal Neovascularization/pathology
- Zebrafish/embryology*
- PubMed
- 27085972 Full text @ BBA Molecular Basis of Disease
Citation
Rezzola, S., Paganini, G., Semeraro, F., Presta, M., Tobia, C. (2016) Zebrafish (Danio rerio) embryo as a platform for the identification of novel angiogenesis inhibitors of retinal vascular diseases. Biochimica et biophysica acta. Molecular basis of disease. 1862(7):1291-6.
Abstract
Pathological angiogenesis of the retina is a main cause of blindness. Therapeutic approaches targeting vascular endothelial growth factor, a main angiogenesis inducer in retinal vascular diseases, show significant limitations. Thus, experimental models of retinal neovascularization remain crucial for investigating novel anti-angiogenic strategies and bringing them to patients. Recent observations have shown that eye neovascularization in zebrafish (Danio rerio) embryo may represent a novel target for the identification of angiogenesis inhibitors. This review highlights the use of zebrafish embryo as an innovative model system for the screening of anti-angiogenic molecules to be employed for the treatment of angiogenesis-dependent eye diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping