PUBLICATION
Crossover Inhibition Generates Sustained Visual Responses in the Inner Retina
- Authors
- Rosa, J.M., Ruehle, S., Ding, H., Lagnado, L.
- ID
- ZDB-PUB-160414-11
- Date
- 2016
- Source
- Neuron 90(2): 308-19 (Journal)
- Registered Authors
- Lagnado, Leon
- Keywords
- none
- MeSH Terms
-
- Amacrine Cells/metabolism
- Amacrine Cells/physiology*
- Animals
- GABAergic Neurons/physiology
- Glycine/metabolism
- Glycine/physiology
- Neural Inhibition/physiology*
- Photic Stimulation
- Retina/physiology*
- Retinal Bipolar Cells/physiology*
- Synaptic Transmission/physiology
- Vision, Ocular/physiology*
- Zebrafish
- PubMed
- 27068790 Full text @ Neuron
Citation
Rosa, J.M., Ruehle, S., Ding, H., Lagnado, L. (2016) Crossover Inhibition Generates Sustained Visual Responses in the Inner Retina. Neuron. 90(2):308-19.
Abstract
In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate these sustained channels within the inner retina of zebrafish. In OFF bipolar cells, sustained transmission was found to depend on crossover inhibition from the ON pathway through GABAergic amacrine cells. In ON bipolar cells, the amplitude of low-frequency signals was regulated by glycinergic amacrine cells, while GABAergic inhibition regulated the gain of band-pass signals. We also provide the first functional description of a subset of sustained ON bipolar cells in which synaptic activity was suppressed by fluctuations at frequencies above ∼0.2 Hz. These results map out the basic circuitry by which the inner retina generates sustained visual signals and describes a new function of crossover inhibition.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping