ZFIN ID: ZDB-PUB-160408-4
Pax7 is required for establishment of the xanthophore lineage in zebrafish embryos
Nord, H., Dennhag, N., Muck, J., von Hofsten, J.
Date: 2016
Source: Molecular biology of the cell   27(11): 1853-62 (Journal)
Registered Authors: Muck, Joscha, Nord, Hanna, von Hofsten, Jonas
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning/genetics
  • Body Patterning/physiology
  • Cell Differentiation/genetics
  • Chromatophores
  • Embryo, Nonmammalian/metabolism
  • Gene Expression Regulation, Developmental
  • Melanophores/metabolism
  • Neural Crest/metabolism
  • PAX2 Transcription Factor/genetics*
  • PAX2 Transcription Factor/metabolism*
  • Pigmentation/genetics*
  • Pigmentation/physiology
  • Zebrafish/genetics
  • Zebrafish Proteins/genetics*
  • Zebrafish Proteins/metabolism*
PubMed: 27053658 Full text @ Mol. Biol. Cell
The pigment pattern of many animal species is a result of the arrangement of different types of pigment producing chromatophores. The zebrafish have three different types of chromatophores; black melanophores, yellow xanthophores and shimmering iridophores arranged in a characteristic pattern of golden and blue horizontal stripes. In the zebrafish embryo chromatophores derive from the neural crest cells. Using pax7a and pax7b zebrafish mutants we have identified a previously unknown requirement for Pax7 in the xanthophore lineage formation. The absence of Pax7 results in a severe reduction of xanthophore precursor cells and a complete depletion of differentiated xanthophores in embryos as well as adult zebrafish. In contrast, the melanophore lineage is increased in pax7a/pax7b double mutant embryos and larvae, whereas juvenile and adult pax7a/pax7b double mutant zebrafish display a severe decrease in melanophores and a pigment pattern disorganisation, indicative of a xanthophore deficient phenotype. In summary, we propose a novel role for Pax7 in the early specification of chromatophore precursor cells.