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ZFIN ID: ZDB-PUB-160319-10
Species tailoured contribution of volumetric growth and tissue convergence to posterior body elongation in vertebrates
Steventon, B., Duarte, F., Lagadec, R., Mazan, S., Nicolas, J.F., Hirsinger, E.
Date: 2016
Source: Development (Cambridge, England) 143(10): 1732-41 (Journal)
Registered Authors: Hirsinger, Estelle
Keywords: Multi-scalar morphometric analysis, Zebrafish, Mouse, Lamprey, Dogfish, Energy supply
MeSH Terms:
  • Animals
  • Body Patterning*
  • Cell Movement
  • Cell Proliferation
  • Dogfish/embryology
  • Fibroblast Growth Factors/metabolism
  • Lampreys/embryology
  • Mice
  • Notochord/embryology
  • Organogenesis*
  • Signal Transduction
  • Species Specificity
  • Spinal Cord/embryology
  • Tail
  • Vertebrates/embryology*
  • Zebrafish/embryology
PubMed: 26989170 Full text @ Development
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ABSTRACT
Posterior body elongation is a widespread mechanism propelling the generation of the metazoan body plan. The posterior growth model predicts that a posterior growth zone generates sufficient tissue volume to elongate the posterior body. However, there are energy supply-related differences between vertebrates in the degree to which growth occurs concomitantly with embryogenesis. By applying a multi-scalar morphometric analysis in zebrafish embryos, we show that posterior body elongation is generated by an influx of cells from lateral regions, by convergence-extension of cells as they exit the tailbud, and finally by a late volumetric growth in the spinal cord and notochord. Importantly, the unsegmented region does not generate additional tissue volume. FGF inhibition blocks tissue convergence rather than volumetric growth, showing that a conserved molecular mechanism can control convergent morphogenesis through different cell behaviours. Finally, via a comparative morphometric analysis in lamprey, dogfish, zebrafish and mouse, we propose that elongation via posterior volumetric growth is linked to increased energy supply and is associated with an overall increase in volumetric growth and elongation.
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