PUBLICATION
Aqueous Hg(2+) associates with TiO2 nanoparticles according to particle size, changes particle agglomeration, and becomes less bioavailable to zebrafish
- Authors
- Boran, H., Boyle, D., Altinok, I., Patsiou, D., Henry, T.B.
- ID
- ZDB-PUB-160314-1
- Date
- 2016
- Source
- Aquatic toxicology (Amsterdam, Netherlands) 174: 242-246 (Journal)
- Registered Authors
- Henry, Theodore B.
- Keywords
- Mercury, Metallothionein, Sorption, Titanium dioxide nanoparticles, Zebrafish
- MeSH Terms
-
- Animals
- Biological Availability
- Gene Expression Regulation/drug effects*
- Mercury/chemistry*
- Mercury/toxicity
- Metallothionein/genetics
- Nanoparticles/chemistry*
- Particle Size
- Titanium/chemistry*
- Water Pollutants, Chemical/toxicity
- Zebrafish*
- PubMed
- 26970871 Full text @ Aquat. Toxicol.
Citation
Boran, H., Boyle, D., Altinok, I., Patsiou, D., Henry, T.B. (2016) Aqueous Hg(2+) associates with TiO2 nanoparticles according to particle size, changes particle agglomeration, and becomes less bioavailable to zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 174:242-246.
Abstract
Engineered nanoparticles (NPs) have unique physicochemistry and potential to interact with other substances in the aqueous phase. Here, gene [metallothionein 2 (mt2)] expression changes in larval zebrafish were used to evaluate the association between aqueous Hg(2+) and TiO2 (NPs and bulk particle size control) to investigate the relationship between changes in Hg(2+) behavior and TiO2 size. During 24h exposures, TiO2 agglomerates increased in size and in the presence of 25μg Hg(2+)/L, greater increases in size were observed. The concentration of Hg(2+) in suspension also decreased in the presence of TiO2-NPs. Mercury increased expression of mt2 in larval zebrafish, but this response was lessened when zebrafish were exposed to Hg(2+) in the presence of TiO2-NPs, and which suggests that TiO2-NPs alter the bioavailability of Hg(2+) to zebrafish larvae. This ameliorative effect of TiO2 was also likely due to surface binding of Hg(2+) because a greater decrease in mt2 expression was observed in the presence of 1mg/L TiO2-NPs than 1mg/L TiO2-bulk. In conclusion, the results show that Hg(2+) will associate with TiO2-NPs, TiO2-NPs that have associated Hg(2+) will settle out of the aqueous phase more rapidly, and agglomerates will deliver associated Hg(2+) to sediment surfaces.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping