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ZFIN ID: ZDB-PUB-160313-2
Organ Function as a Modulator of Organ Formation: Lessons from Zebrafish
Collins, M.M., Stainier, D.Y.
Date: 2016
Source: Current topics in developmental biology   117: 417-433 (Chapter)
Registered Authors: Stainier, Didier
Keywords: Cardiac function, Fluid flow, Heart, Hemodynamic forces, Morphogenesis, Organogenesis, Shear stress, Trabeculation, Valve, Zebrafish
MeSH Terms:
  • Animals
  • Heart/embryology
  • Heart/growth & development*
  • Morphogenesis/physiology*
  • Myocytes, Cardiac/cytology*
  • Zebrafish/embryology*
PubMed: 26969993 Full text @ Curr. Top. Dev. Biol.
Organogenesis requires an intricate balance between cell differentiation and tissue growth to generate a complex and fully functional organ. However, organogenesis is not solely driven by genetic inputs, as the development of several organ systems requires their own functionality. This theme is particularly evident in the developing heart as progression of cardiac development is accompanied by increased and altered hemodynamic forces. In the absence or disruption of these forces, heart development is abnormal, suggesting that the heart must sense these changes and respond appropriately. Here, we discuss concepts of how embryonic heart function contributes to heart development using lessons learned mostly from studies in zebrafish.