ZFIN ID: ZDB-PUB-160310-13
Interplay between cardiac function and heart development
Andrés-Delgado, L., Mercader, N.
Date: 2016
Source: Biochimica et biophysica acta. Molecular cell research   1863(7 Pt B): 1707-16 (Review)
Registered Authors: Mercader Huber, Nadia
Keywords: Blood and pericardial flow, Cardiac development, Mechanosensing, Mechanotransduction, Mouse, Zebrafish
MeSH Terms:
  • Action Potentials
  • Adaptation, Physiological
  • Age Factors
  • Animals
  • Coronary Circulation*
  • Heart/embryology
  • Heart/growth & development*
  • Heart Diseases/pathology
  • Heart Diseases/physiopathology
  • Hemodynamics*
  • Humans
  • Mechanotransduction, Cellular*
  • Morphogenesis
  • Myocytes, Cardiac/metabolism
  • Myocytes, Cardiac/physiology*
  • Regeneration
  • Stress, Mechanical
PubMed: 26952935 Full text @ BBA Molecular Cell Research
Mechanotransduction refers to the conversion of mechanical forces into biochemical or electrical signals that initiate structural and functional remodeling in cells and tissues. The heart is a kinetic organ whose form changes considerably during development and disease. This requires cardiomyocytes to be mechanically durable and able to mount coordinated responses to a variety of environmental signals on different time scales, including cardiac pressure loading and electrical and hemodynamic forces. During physiological growth, myocytes, endocardial and epicardial cells have to adaptively remodel to these mechanical forces. Here we review some of the recent advances in the understanding of how mechanical forces influence cardiac development, with a focus on fluid flow forces. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Develomental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.