PUBLICATION

Histone deacetylase 1 is required for the development of the zebrafish inner ear

Authors
He, Y., Tang, D., Li, W., Chai, R., Li, H.
ID
ZDB-PUB-160203-6
Date
2016
Source
Scientific Reports   6: 16535 (Journal)
Registered Authors
Keywords
Differentiation, Disease model
MeSH Terms
  • Animals
  • Ear, Inner/embryology*
  • Fibroblast Growth Factors/genetics
  • Fibroblast Growth Factors/metabolism
  • Gene Knockdown Techniques
  • Histone Deacetylase 1/genetics
  • Histone Deacetylase 1/metabolism*
  • Signal Transduction/physiology*
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed
26832938 Full text @ Sci. Rep.
Citation
He, Y., Tang, D., Li, W., Chai, R., Li, H. (2016) Histone deacetylase 1 is required for the development of the zebrafish inner ear. Scientific Reports. 6:16535.
Abstract
Histone deacetylase 1 (HDAC1) has been reported to be important for multiple aspects of normal embryonic development, but little is known about its function in the development of mechanosensory organs. Here, we first confirmed that HDAC1 is expressed in the developing otic vesicles of zebrafish by whole-mount in situ hybridization. Knockdown of HDAC1 using antisense morpholino oligonucleotides in zebrafish embryos induced smaller otic vesicles, abnormal otoliths, malformed or absent semicircular canals, and fewer sensory hair cells. HDAC1 loss of function also caused attenuated expression of a subset of key genes required for otic vesicle formation during development. Morpholino-mediated knockdown of HDAC1 resulted in decreased expression of members of the Fgf family in the otic vesicles, suggesting that HDAC1 is involved in the development of the inner ear through regulation of Fgf signaling pathways. Taken together, our results indicate that HDAC1 plays an important role in otic vesicle formation.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.