PUBLICATION

Input overload: Contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis

Authors
D'Aniello, E., Waxman, J.S.
ID
ZDB-PUB-160106-13
Date
2015
Source
Developmental dynamics : an official publication of the American Association of Anatomists   244(3): 513-23 (Review)
Registered Authors
Waxman, Joshua
Keywords
cardiac progenitors; development; heart; morphogen; patterning; retinoic acid; signaling feedback; teratogenesis; transcriptional regulation; vertebrates; vitamin A
MeSH Terms
  • Animals
  • Heart/embryology*
  • Heart Defects, Congenital/embryology*
  • Humans
  • Teratogenesis*
  • Tretinoin/metabolism*
PubMed
25418431 Full text @ Dev. Dyn.
Abstract
Appropriate levels of retinoic acid (RA) signaling are critical for normal heart development in vertebrates. A fascinating property of RA signaling is the thoroughness by which positive and negative feedback are employed to promote proper embryonic RA levels. In the present short review, we first cover the advancement of hypotheses regarding the impact of RA signaling on cardiac specification. We then discuss our current understanding of RA signaling feedback mechanisms and the implications of recent studies, which have indicated improperly maintained RA signaling feedback can be a contributing factor to developmental malformations.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping