ZFIN ID: ZDB-PUB-160106-13
Input overload: Contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis
D'Aniello, E., Waxman, J.S.
Date: 2015
Source: Developmental dynamics : an official publication of the American Association of Anatomists   244(3): 513-23 (Review)
Registered Authors: Waxman, Joshua
Keywords: cardiac progenitors; development; heart; morphogen; patterning; retinoic acid; signaling feedback; teratogenesis; transcriptional regulation; vertebrates; vitamin A
MeSH Terms:
  • Animals
  • Heart/embryology*
  • Heart Defects, Congenital/embryology*
  • Humans
  • Teratogenesis*
  • Tretinoin/metabolism*
PubMed: 25418431 Full text @ Dev. Dyn.
Appropriate levels of retinoic acid (RA) signaling are critical for normal heart development in vertebrates. A fascinating property of RA signaling is the thoroughness by which positive and negative feedback are employed to promote proper embryonic RA levels. In the present short review, we first cover the advancement of hypotheses regarding the impact of RA signaling on cardiac specification. We then discuss our current understanding of RA signaling feedback mechanisms and the implications of recent studies, which have indicated improperly maintained RA signaling feedback can be a contributing factor to developmental malformations.