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ZFIN ID: ZDB-PUB-151216-9
Omeprazole inhibits melanin biosynthesis in melan-a cells and zebrafish
Baek, S.H., Lee, S.H.
Date: 2016
Source: Experimental dermatology   25(3): 239-41 (Journal)
Registered Authors:
Keywords: antimelanogenic effects, melanogensis-related proteins, microphthalmia-associated transcription factor, omeprazole, zebrafish
MeSH Terms:
  • Animals
  • Arbutin/chemistry
  • Cell Line
  • Copper/chemistry
  • Dose-Response Relationship, Drug
  • Gene Expression Regulation, Developmental/drug effects
  • Melanins/biosynthesis*
  • Melanocytes/drug effects*
  • Mice
  • Microphthalmia-Associated Transcription Factor/metabolism
  • Omeprazole/chemistry*
  • Pigmentation/drug effects
  • Proton Pump Inhibitors/chemistry
  • Skin/drug effects*
  • Tyrosine/chemistry
  • Zebrafish
PubMed: 26660505 Full text @ Exp. Dermatol.
Recently, it was demonstrated that OMP significantly exhibited antimelanogenic activity via the ATP7A-dependent transport of copper to tyrosinase (9). However, OMP’s inhibitory effect on melanin biosynthesis via MAPKs has not yet been examined. In this study, we investigated whether the effect of MAPK signalling on zebrafish melanin formation is regulated by OMP.