PUBLICATION
Fish genomics: casting the net wide
- Authors
- Wardle, F., Muller, F.
- ID
- ZDB-PUB-150818-1
- Date
- 2014
- Source
- Briefings in Functional Genomics 13: 79-81 (Other)
- Registered Authors
- Wardle, Fiona
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Embryonic Development/genetics
- Epigenesis, Genetic
- Fishes/embryology
- Fishes/genetics*
- Genome/genetics
- Genomics*
- Humans
- Zebrafish/embryology
- Zebrafish/genetics
- PubMed
- 24632186 Full text @ Brief. Funct. Genomics
Citation
Wardle, F., Muller, F. (2014) Fish genomics: casting the net wide. Briefings in Functional Genomics. 13:79-81.
Abstract
Recent developments in high-throughput genomics, including the landmark ENCODE project [1], have generated an immense amount of data that motivates scholars from a wide range of fields well beyond genomics. The comprehensive attempt to annotate the human genome however raised an important problem: the need for a suitable, preferably, in vivo animal model that enables high-throughput in vivo functional testing of hypotheses generated from genome scale annotation data. Small fish models such as zebrafish (Danio rerio) and medaka (Oryzias latipes) are ideal vertebrates with sufficiently high-throughput capabilities to aspire to these large-scale experimental studies and thus may provide a suitable animal model for functional analyses of annotated genomics features. This notion is demonstrated by the ENCODE publications, one of which features medaka transgenesis experiments in validation of predicted regulatory elements [1]. However, the degree to which fish can suffice as a surrogate for mammalian functional genomics will depend on our ability to understand the extent of underlying homology and functional parallels between mammals and fish and, most importantly, will require better annotation of fish genomes throughout ontogeny.
The widening application of genomics technologies to fish model systems have led to a series of important advances in this area, which look set to propel fish and particularly zebrafish, into a new era of discovery [2]. This timely special issue on fish genomics features articles, which provides an overview of several key areas where fish models have contributed substantially to the disciplines of genetics, epigenetics and (epi)genomics and demonstrates the strengthening position of …
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping