PUBLICATION
Putative involvement of the nitrergic system on the consolidation, but not initiation, of behavioral sensitization after conspecific alarm substance in zebrafish
- Authors
- Lima, M.G., Rodrigues, S.N., Silva, R.X., Oliveira, K.R., Batista, E.J., Maximino, C., Herculano, A.M.
- ID
- ZDB-PUB-150811-2
- Date
- 2015
- Source
- Pharmacology, biochemistry, and behavior 139 Pt B: 127-33 (Journal)
- Registered Authors
- Lima, Monica Gomes, Maximino, Caio
- Keywords
- Behavioral sensitization, Long-term stress sensitization, Nitric oxide, Predator threat, Zebrafish
- MeSH Terms
-
- Animals
- Anxiety/etiology
- Anxiety/physiopathology
- Anxiety/prevention & control
- Behavior, Animal/drug effects
- Behavior, Animal/physiology*
- Disease Models, Animal
- Enzyme Inhibitors/pharmacology
- NG-Nitroarginine Methyl Ester/pharmacology
- Nitric Oxide/physiology*
- Nitric Oxide Synthase/antagonists & inhibitors
- Stress, Physiological
- Zebrafish/physiology*
- PubMed
- 26257339 Full text @ Pharmacol. Biochem. Behav.
Citation
Lima, M.G., Rodrigues, S.N., Silva, R.X., Oliveira, K.R., Batista, E.J., Maximino, C., Herculano, A.M. (2015) Putative involvement of the nitrergic system on the consolidation, but not initiation, of behavioral sensitization after conspecific alarm substance in zebrafish. Pharmacology, biochemistry, and behavior. 139 Pt B:127-33.
Abstract
Stressful manipulations can sensitize the behavior of an organism, increasing anxiety-like behavior after a delay; this long-term stress sensitization can represent the pathophysiological basis of trauma- and stress-related disorders (TRSDs), of which the most prevalent is post-traumatic stress disorder (PTSD). A role for the glutamate-nitric oxide pathway in this sensitization is implied by behavioral, neurophysiological and genomic data on different species. Here, we report on the long-term sensitization of anxiety-like behavior in zebrafish and the possible participation of nitric oxide in this process. Zebrafish exposed to a conspecific alarm substance (AS) show increased anxiety-like behavior at least 24h after stimulus delivery. Blocking nitric oxide synthesis with l-NAME (5mg/kg) 30min, but not 90min, after AS exposure blocks the sensitization of scototaxis and risk assessment, while treatment 90min after exposure blocks the sensitization of thigmotaxis and erratic swimming; l-NAME was not effective when administered 30min before AS exposure. These data suggest a participation of nitric oxide in the consolidation, but not in the initiation, of behavioral sensitization after predator threat.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping