PUBLICATION
[Looking through zebrafish to study host-pathogen interactions]
- Authors
- Bernut, A., Lutfalla, G., Kremer, L.
- ID
- ZDB-PUB-150711-16
- Date
- 2015
- Source
- Medecine sciences : M/S 31: 638-46 (Journal)
- Registered Authors
- Lutfalla, Georges
- Keywords
- none
- MeSH Terms
-
- Animals
- Bacteria/pathogenicity
- Disease Models, Animal*
- Embryo, Nonmammalian
- Fungi/pathogenicity
- Host-Pathogen Interactions*/immunology
- Humans
- Infections/immunology
- Infections/pathology*
- Infections/physiopathology
- Viruses/pathogenicity
- Zebrafish*/embryology
- Zebrafish*/growth & development
- Zebrafish*/immunology
- PubMed
- 26152168 Full text @ Med. Sci. (Paris)
Citation
Bernut, A., Lutfalla, G., Kremer, L. (2015) [Looking through zebrafish to study host-pathogen interactions]. Medecine sciences : M/S. 31:638-46.
Abstract
The zebrafish offers many advantages that motivated and validated its use to study the virulence of numerous human pathogens, including viruses, bacteria and fungi. Its immune system is homologous to the one of mammals. The optical transparency of zebrafish embryos allows non-invasive and real-time monitoring of the infection processes through the use of imaging techniques. The zebrafish is therefore a useful and powerful model to study host-pathogen interactions at a cellular level. It may be used to describe pathophysiological events and subversion mechanisms that are specific to each pathogen. In addition to increasing our understanding of the host immune defense, this model is of high potential for medical application, being particularly amenable to high-throughput screening for the discovery of new anti-infective molecules.
Errata / Notes
Article in French.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping