PUBLICATION
Effects of Atrazine on the Development of Neural System of Zebrafish, Danio rerio
- Authors
- Wang, H., Mu, S., Zhang, F., Wang, H., Liu, H., Zhang, H., Kang, X.
- ID
- ZDB-PUB-150627-1
- Date
- 2015
- Source
- BioMed Research International 2015: 976068 (Journal)
- Registered Authors
- Wang, Hao
- Keywords
- none
- MeSH Terms
-
- Animals
- Atrazine/administration & dosage*
- Atrazine/toxicity
- Embryo, Nonmammalian/drug effects
- Embryonic Development/drug effects*
- Embryonic Development/immunology
- Larva
- Sarcomeres/drug effects*
- Sarcomeres/metabolism
- Sensory Receptor Cells/drug effects*
- Water Pollutants, Chemical/toxicity
- Zebrafish/embryology
- PubMed
- 26114119 Full text @ Biomed Res. Int.
Citation
Wang, H., Mu, S., Zhang, F., Wang, H., Liu, H., Zhang, H., Kang, X. (2015) Effects of Atrazine on the Development of Neural System of Zebrafish, Danio rerio. BioMed Research International. 2015:976068.
Abstract
By comparative analysis of histomorphology and AChE activity, the changes of physiological and biochemical parameters were determined in zebrafish embryos and larvae dealt with atrazine (ATR) at different concentrations (0.0001, 0.001, 0.01, 0.1, and 1 mg/L). This study showed that the development of the sarcomere and the arrangement of white muscle myofibers were affected by ATR significantly and the length of sarcomere shortened. Further analysis of the results showed that the AChE activity in juvenile fish which was treated with ATR was downregulated, which can indicate that the innervation efficiency to the muscle was impaired. Conversely, the AChE activity in zebrafish embryos which was treated with ATR was upregulated. A parallel phenomenon showed that embryonic primary sensory neurons (Rohon-Beard cells), principally expressing AChE in embryos, survived the physiological apoptosis. These phenomena demonstrated that the motor integration ability of the zebrafish was damaged by ATR which can disturb the development of sensory neurons and sarcomere and the innervations of muscle.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping