ZFIN ID: ZDB-PUB-150625-3
Evidence for a Role of the Transcriptional Regulator Maid in Tumorigenesis and Aging
Fujisawa, K., Terai, S., Matsumoto, T., Takami, T., Yamamoto, N., Nishina, H., Furutani-Seiki, M., Sakaida, I.
Date: 2015
Source: PLoS One   10: e0129950 (Journal)
Registered Authors: Furutani-Seiki, Makoto
Keywords: none
MeSH Terms:
  • Aging/genetics*
  • Amino Acid Sequence
  • Animals
  • Animals, Genetically Modified
  • Carcinogenesis/genetics*
  • Carcinoma, Hepatocellular/metabolism
  • Cell Line
  • Cell Transformation, Neoplastic*
  • Diethylnitrosamine/chemistry
  • Disease Models, Animal
  • Disease Progression
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Liver Neoplasms/metabolism
  • Mice
  • Molecular Sequence Data
  • Oligonucleotide Array Sequence Analysis
  • Oryzias
  • Phylogeny
  • Sequence Homology, Amino Acid
  • Transcription Factors/genetics
  • Transcription Factors/physiology*
  • Zebrafish
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/physiology*
PubMed: 26107180 Full text @ PLoS One
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ABSTRACT
Maid is a helix-loop-helix protein that is involved in cell proliferation. In order to further elucidate its physiological functions, we studied Maid activity in two small fish model systems. We found that Maid expression was greatest in zebrafish liver and that it increased following partial hepatectomy. Maid levels were also high in hepatic preneoplastic foci induced by treatment of zebrafish with diethylnitrosamine (DEN), but low in hepatocellular carcinomas (HCC), mixed tumors, and cholangiocarcinomas developing in these animals. In DEN-treated transgenic medaka overexpressing Maid, hepatic BrdU uptake and proliferation were reduced. After successive breedings, Maid transgenic medaka exhibited decreased movement and a higher incidence of abnormal spine curvature, possibly due to the senescence of spinal cord cells. Taken together, our results suggest that Maid levels can influence the progression of liver cancer. In conclusion, we found that Maid is important regulator of hepatocarconogenesis and aging.
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