ZFIN ID: ZDB-PUB-150614-2
Cross-species oncogenomics using zebrafish models of cancer
White, R.M.
Date: 2015
Source: Current opinion in genetics & development   30: 73-9 (Other)
Registered Authors: White, Richard M.
Keywords: none
MeSH Terms:
  • Animals
  • Disease Models, Animal*
  • Fish Diseases/genetics
  • Humans
  • Neoplasms/genetics*
  • Zebrafish*
PubMed: 26070506 Full text @ Curr. Opin. Genet. Dev.
The zebrafish is a relatively recent addition to cancer modeling. These models have now been extensively used in cross-species oncogenomic analyses at both the DNA and RNA levels. The goal of such studies is to identify conserved events that occur in both human and fish tumors which may act as central drivers of tumor phenotypes. Numerous comparisons of somatic DNA changes, using array CGH and exome sequencing, have demonstrated a relatively small set of conserved changes across species. In contrast, striking conservation of RNA expression patterns have been observed between the two species in models such as melanoma, leukemia, and rhabdomyosarcoma. In the future, the zebrafish will increasingly be used to model epigenetic and noncoding aspects of cancer biology.