PUBLICATION
Individual Cell Migration Serves as the Driving Force for Optic Vesicle Evagination
- Authors
- Rembold, M., Loosli, F., Adams, R. J., Wittbrodt, J.
- ID
- ZDB-PUB-150422-16
- Date
- 2006
- Source
- Science (New York, N.Y.) 313: 1130-1134 (Journal)
- Registered Authors
- Adams, Richard, Loosli, Felix, Rembold, Martina, Wittbrodt, Jochen
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Cell Movement*
- Cell Shape
- Central Nervous System/embryology
- Epithelial Cells/cytology
- Epithelial Cells/physiology
- Eye/embryology*
- Fish Proteins/genetics
- Fish Proteins/physiology
- Gastrula/cytology
- Homeodomain Proteins/genetics
- Homeodomain Proteins/physiology
- Image Processing, Computer-Assisted
- Microscopy, Confocal
- Morphogenesis
- Mutation
- Oryzias/embryology*
- Oryzias/genetics
- Prosencephalon/embryology
- Retina/cytology
- Retina/embryology*
- Stem Cell Transplantation
- Stem Cells/physiology*
- PubMed
- 16931763 Full text @ Science
Citation
Rembold, M., Loosli, F., Adams, R. J., Wittbrodt, J. (2006) Individual Cell Migration Serves as the Driving Force for Optic Vesicle Evagination. Science (New York, N.Y.). 313:1130-1134.
Abstract
The cellular mechanisms underlying organ formation are largely unknown. We visualized early vertebrate eye morphogenesis at single-cell resolution by in vivo imaging in medaka (Oryzias latipes). Before optic vesicle evagination, retinal progenitor cells (RPCs) modulate their convergence in a fate-specific manner. Presumptive forebrain cells converge toward the midline, whereas medial RPCs remain stationary, predetermining the site of evagination. Subsequent optic vesicle evagination is driven by the active migration of individual RPCs. The analysis of mutants demonstrated that the retina-specific transcription factor rx3 determines the convergence and migration behaviors of RPCs. Hence, the migration of individual cells mediates essential steps of organ morphogenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping