PUBLICATION
Cyhalofop-butyl has the potential to induce developmental toxicity, oxidative stress and apoptosis in early life stage of zebrafish (Danio rerio)
- Authors
- Zhu, L., Mu, X., Wang, K., Chai, T., Yang, Y., Qiu, L., Wang, C.
- ID
- ZDB-PUB-150413-1
- Date
- 2015
- Source
- Environmental pollution (Barking, Essex : 1987) 203: 40-49 (Journal)
- Registered Authors
- Keywords
- Apoptosis, Cyhalofop-butyl, Developmental toxicity, Oxidative stress, Zebrafish embryo
- MeSH Terms
-
- Animals
- Apoptosis/drug effects
- Butanes/toxicity*
- Caspase 3/metabolism
- Caspase 9/metabolism
- Embryo, Nonmammalian/drug effects
- Embryo, Nonmammalian/metabolism
- Embryonic Development/drug effects*
- Female
- Herbicides/toxicity*
- Male
- Nitriles/toxicity*
- Oxidative Stress/drug effects
- Reactive Oxygen Species/metabolism
- Zebrafish/embryology*
- Zebrafish/metabolism
- PubMed
- 25863881 Full text @ Environ. Pollut.
Citation
Zhu, L., Mu, X., Wang, K., Chai, T., Yang, Y., Qiu, L., Wang, C. (2015) Cyhalofop-butyl has the potential to induce developmental toxicity, oxidative stress and apoptosis in early life stage of zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 203:40-49.
Abstract
Cyhalofop-butyl is a selective herbicide widely employed in paddy field, which can transfer into aquatic environments. However, details of the environmental risk and aquatic toxicity of cyhalofop-butyl have not been fully investigated. In this study, zebrafish (Danio rerio) embryos were exposed to a range of cyhalofop-butyl until 120 hour post-fertilization (hpf) to assess embryonic toxicity of the chemical. Our results demonstrated that cyhalofop-butyl was highly toxic to zebrafish embryos, with concentration-dependent negative effects in embryonic development. In addition, exposure to cyhalofop-butyl resulted in significant increases in reactive oxygen species (ROS) production and cell apoptosis in heart area. The mRNA levels of the genes related to oxidative stress and apoptosis were also altered significantly after cyhalofop-butyl exposure. Moreover, the activity of capspase-9 and caspase-3 were significantly increased. Therefore, we speculated that oxidative stress-induced apoptosis should be responsible for abnormal development during embryogenesis after cyhalofop-butyl exposure.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping