PUBLICATION
Antiepileptic C21 steroids from the roots of Cynanchum otophyllum
- Authors
- Li, X., Zhang, M., Xiang, C., Li, B.C., Li, P.
- ID
- ZDB-PUB-150113-4
- Date
- 2015
- Source
- Journal of Asian natural products research 17(7): 724-32 (Journal)
- Registered Authors
- Li, Xiang
- Keywords
- C21 steroid, Cynanchum otophyllum, antiepileptic effect, zebrafish
- MeSH Terms
-
- Animals
- Anticonvulsants/chemistry
- Anticonvulsants/isolation & purification*
- Anticonvulsants/pharmacology*
- Cynanchum/chemistry*
- Glycosides/chemistry
- Glycosides/isolation & purification*
- Glycosides/pharmacology*
- Larva/drug effects
- Molecular Structure
- Nuclear Magnetic Resonance, Biomolecular
- Plant Roots/chemistry
- Steroids/chemistry
- Steroids/isolation & purification*
- Steroids/pharmacology
- Zebrafish
- PubMed
- 25579837 Full text @ J Asian Nat Prod Res
Citation
Li, X., Zhang, M., Xiang, C., Li, B.C., Li, P. (2015) Antiepileptic C21 steroids from the roots of Cynanchum otophyllum. Journal of Asian natural products research. 17(7):724-32.
Abstract
In order to discover more natural products possessing potentially antiepileptic activities, three C21 steroids, including a new one, characterized as caudatin-3-O-β-d-cymaropyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-cymaropyranoside (1), and two known analogs, otophylloside B (2) and caudatin-3-O-β-d-oleandropyranosyl-(1 → 4)-β-d-oleandropyranosyl-(1 → 4)-β-d-cymaropyranosyl-(1 → 4)-β-d-cymaropyranoside (3), were isolated from the chloroform extract of the roots of Cynanchum otophyllum and evaluated for their antiepileptic activities by pentylenetrazole (PTZ)-induced zebrafish larval locomotor assay. The results showed that all of them had marked activities of suppressing PTZ-induced seizure behaviors in larval zebrafish at the dose of 10 μg/ml.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping