PUBLICATION
On the tubulin polymerization promoting proteins of zebrafish
- Authors
- Orosz, F.
- ID
- ZDB-PUB-150113-10
- Date
- 2015
- Source
- Biochemical and Biophysical Research Communications 457(3): 267-72 (Journal)
- Registered Authors
- Keywords
- Genome duplication, Lamprey, Synteny, Tubulin polymerization promoting proteins (TPPPs), Zebrafish
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA/genetics
- Humans
- Molecular Sequence Data
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/metabolism*
- Protein Multimerization
- Sequence Homology, Amino Acid
- Tubulin/chemistry*
- Tubulin/metabolism*
- Tubulin Modulators/metabolism*
- Zebrafish/genetics
- Zebrafish/metabolism
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 25576359 Full text @ Biochem. Biophys. Res. Commun.
Citation
Orosz, F. (2015) On the tubulin polymerization promoting proteins of zebrafish. Biochemical and Biophysical Research Communications. 457(3):267-72.
Abstract
Recently, Aoki et al.[15] have been published a paper (Biochem. Biophys. Res. Commun. 445 (2014) 357-362.) in which they identified possible downstream genes required for the extension of peripheral axons in primary sensory neurons of zebrafish. Tppp was claimed as one of them but, as I show, it is the tppp3-like gene, a paralog of tppp, which plays this role. There are three tppp paralogs in fishes: tppp1 (named also tppp), tppp3 and tppp3-like. Tppp1 and tppp3 are the orthologs of the corresponding human genes, however, the classification of the third one is ambiguous. It is known that the genomes of the early vertebrate lineage underwent two complete genome duplications, which result in the presence of several paralogs in vertebrates. A teleost fish specific third whole genome duplication also occurred. Thus the tppp3-like gene can be either an ortholog of human TPPP2 or a fourth paralog (tppp4) absent in tetrapods but present in fishes; finally a tppp3a gene which can be originated from the third, fish specific, whole genome duplication. Comparing the sequences of vertebrate and recently available lamprey tppps I show that the tppp3-like gene is a TPPP2 ortholog. Synteny data are in accordance with this suggestion.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping