ZFIN ID: ZDB-PUB-150103-4
Recent advances in the study of zebrafish extracellular matrix proteins
Jessen, J.R.
Date: 2015
Source: Developmental Biology   401(1): 110-21 (Review)
Registered Authors: Jessen, Jason R.
Keywords: Collagen, Extracellular matrix, Fibronectin, Laminin, Morphogenesis, Zebrafish
MeSH Terms:
  • Animals
  • Body Patterning/physiology
  • Cell Movement/physiology*
  • Cell Polarity/physiology*
  • Collagen/metabolism
  • Extracellular Matrix Proteins/metabolism*
  • Fibronectins/metabolism
  • Gastrula/embryology
  • Heart/embryology*
  • Laminin/metabolism
  • Morphogenesis/physiology*
  • Muscle Contraction/physiology
  • Neural Crest/embryology
  • Somites/physiology*
  • Zebrafish/embryology*
  • Zebrafish/metabolism
PubMed: 25553981 Full text @ Dev. Biol.
The zebrafish extracellular matrix (ECM) is a dynamic and pleomorphic structure consisting of numerous proteins that together regulate a variety of cellular and morphogenetic events beginning as early as gastrulation. The zebrafish genome encodes a similar complement of ECM proteins as found in other vertebrate organisms including glycoproteins, fibrous proteins, proteoglycans, glycosaminoglycans, and interacting or modifying proteins such as integrins and matrix metalloproteinases. As a genetic model system combined with its amenability to high-resolution microscopic imaging, the zebrafish allows interrogation of ECM protein structure and function in both the embryo and adult. Accumulating data have identified important roles for zebrafish ECM proteins in processes as diverse as cell polarity, migration, tissue mechanics, organ laterality, muscle contraction, and regeneration. In this review, I highlight recently published data on these topics that demonstrate how the ECM proteins fibronectin, laminin, and collagen contribute to zebrafish development and adult homeostasis.