PUBLICATION
Interaction between 5-HT1B receptors and nitric oxide in zebrafish responses to novelty
- Authors
- Maximino, C., Lima, M.G., Batista, E.J., Oliveira, K.R., Herculano, A.M.
- ID
- ZDB-PUB-141230-3
- Date
- 2015
- Source
- Neuroscience letters 588: 54-6 (Journal)
- Registered Authors
- Lima, Monica Gomes, Maximino, Caio
- Keywords
- Anxiety, Nitric oxide, Novelty, Serotonin, Zebrafish
- MeSH Terms
-
- Animals
- Drug Inverse Agonism
- Exploratory Behavior
- NG-Nitroarginine Methyl Ester/pharmacology
- Nitric Oxide/metabolism*
- Nitric Oxide Synthase/antagonists & inhibitors
- Nitric Oxide Synthase/metabolism
- Piperidones/pharmacology
- Receptor, Serotonin, 5-HT1B/metabolism*
- Spiro Compounds/pharmacology
- Zebrafish/physiology*
- PubMed
- 25545556 Full text @ Neurosci. Lett.
Citation
Maximino, C., Lima, M.G., Batista, E.J., Oliveira, K.R., Herculano, A.M. (2015) Interaction between 5-HT1B receptors and nitric oxide in zebrafish responses to novelty. Neuroscience letters. 588:54-6.
Abstract
Nitric oxide (NO) and serotonin (5-HT) interact at the molecular and systems levels to control behavioral variables, including agression, fear, and reactions to novelty. In zebrafish, the 5-HT1B receptor has been implicated in anxiety and reactions to novelty, while the 5-HT1A receptor is associated with anxiety-like behavior; this role of the 5-HT1A receptor is mediated by NO. This work investigated whether NO also participates in the mediation of novelty responses by the 5-HT1B receptor. The 5-HT1B receptor inverse agonist SB 224,289 decreased bottom-dwelling and erratic swimming in zebrafish; the effects on bottom-dwelling, but not on erratic swimming, were blocked by pre-treatment with the nitric oxide synthase inhibitor L-NAME. These effects underline a novel mechanism by which 5-HT controls zebrafish reactivity to novel environments, with implications for the study of neotic reactions, exploratory behavior, and anxiety-like states.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping