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ZFIN ID: ZDB-PUB-141204-5
Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms
Ceinos, R.M., Guillot, R., Kelsh, R.N., Cerdá-Reverter, J.M., Rotllant, J.
Date: 2015
Source: Pigment cell & melanoma research   28(2): 196-209 (Journal)
Registered Authors: Cerdá-Reverter, José Miguel, Kelsh, Robert, Rotllant, Josep
Keywords: asip1, dct, ltk, mitfa, tyrp1b, xdh, Agouti, chromatophore, iridophore, melanocyte, melanophore, pigment pattern formation, transgenic, zebrafish
MeSH Terms:
  • Animals
  • Cell Count
  • Gene Expression Regulation, Developmental
  • Larva/genetics
  • Melanophores/metabolism
  • Pigmentation*/genetics
  • RNA, Messenger/genetics
  • RNA, Messenger/metabolism
  • Time Factors
  • Zebrafish/genetics
  • Zebrafish/growth & development
  • Zebrafish/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 25469713 Full text @ Pigment Cell Melanoma Res.
Dorso-ventral pigment pattern differences are the most widespread pigmentary adaptations in vertebrates. In mammals, this pattern is controlled by regulating melanin chemistry in melanocytes using a protein, ASIP. In fish, studies of pigment patterning have focused on stripe formation, identifying a core striping mechanism dependent upon interactions between different pigment cell types. In contrast, mechanisms driving the dorso-ventral countershading pattern have been overlooked. Here, we demonstrate that, in fact, zebrafish utilize two distinct adult pigment patterning mechanisms - an ancient dorso-ventral patterning mechanism, and a more recent striping mechanism based on cell-cell interactions; remarkably, the dorso-ventral patterning mechanism also utilizes ASIP. These two mechanisms function largely independently, with resultant patterns superimposed to give the full pattern. This article is protected by copyright. All rights reserved.