ZFIN ID: ZDB-PUB-141204-5
Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms
Ceinos, R.M., Guillot, R., Kelsh, R.N., Cerdá-Reverter, J.M., Rotllant, J.
Date: 2015
Source: Pigment cell & melanoma research 28(2): 196-209 (Journal)
Registered Authors: Cerdá-Reverter, José Miguel, Kelsh, Robert, Rotllant, Josep
Keywords: asip1, dct, ltk, mitfa, tyrp1b, xdh, Agouti, chromatophore, iridophore, melanocyte, melanophore, pigment pattern formation, transgenic, zebrafish
MeSH Terms: Animals; Cell Count; Gene Expression Regulation, Developmental; Larva/genetics; Melanophores/metabolism (all 14) expand
PubMed: 25469713 Full text @ Pigment Cell Melanoma Res.
FIGURES   (current status)
Dorso-ventral pigment pattern differences are the most widespread pigmentary adaptations in vertebrates. In mammals, this pattern is controlled by regulating melanin chemistry in melanocytes using a protein, ASIP. In fish, studies of pigment patterning have focused on stripe formation, identifying a core striping mechanism dependent upon interactions between different pigment cell types. In contrast, mechanisms driving the dorso-ventral countershading pattern have been overlooked. Here, we demonstrate that, in fact, zebrafish utilize two distinct adult pigment patterning mechanisms - an ancient dorso-ventral patterning mechanism, and a more recent striping mechanism based on cell-cell interactions; remarkably, the dorso-ventral patterning mechanism also utilizes ASIP. These two mechanisms function largely independently, with resultant patterns superimposed to give the full pattern. This article is protected by copyright. All rights reserved.