PUBLICATION
Effect of titanium dioxide nanoparticles on the bioavailability, metabolism, and toxicity of pentachlorophenol in zebrafish larvae
- Authors
- Fang, Q., Shi, X., Zhang, L., Wang, Q., Wang, X., Guo, Y., Zhou, B.
- ID
- ZDB-PUB-141203-2
- Date
- 2015
- Source
- Journal of hazardous materials 283C: 897-904 (Journal)
- Registered Authors
- Keywords
- Bioavailability and metabolism, Nano-titanium dioxide, Oxidative damage, Pentachlorophenol, Zebrafish larvae
- MeSH Terms
-
- Animals
- Biological Availability
- DNA Damage
- Embryo, Nonmammalian/drug effects
- Larva/drug effects
- Lipid Peroxidation
- Metal Nanoparticles/chemistry*
- Oxidative Stress
- Pentachlorophenol/metabolism*
- Pentachlorophenol/toxicity*
- Reactive Oxygen Species/metabolism
- Titanium/chemistry*
- Water Pollutants, Chemical/metabolism
- Water Pollutants, Chemical/toxicity
- Zebrafish*/embryology
- PubMed
- 25464334 Full text @ J. Hazard. Mater.
Citation
Fang, Q., Shi, X., Zhang, L., Wang, Q., Wang, X., Guo, Y., Zhou, B. (2015) Effect of titanium dioxide nanoparticles on the bioavailability, metabolism, and toxicity of pentachlorophenol in zebrafish larvae. Journal of hazardous materials. 283C:897-904.
Abstract
This study investigated the influence of titanium dioxide nanoparticles (n-TiO2) on the bioavailability, metabolism, and toxicity of pentachlorophenol (PCP) in fish. Zebrafish (Danio rerio) embryos or larvae (2-h post-fertilization) were exposed to PCP (0, 3, 10, and 30μg/L) alone or in combination with n-TiO2 (0.1mg/L) until 6 days post-fertilization. Results showed that n-TiO2 treatment alone did not induce lipid peroxidation, DNA damage, as well as the generation of reactive oxygen species (ROS) in the larvae. As compared with PCP treatment, the co-exposure of PCP and n-TiO2 enhanced the induction of ROS generation, eventually leading to lipid peroxidation and DNA damage. The nuclear factor erythroid 2-related factor 2 gene transcriptions were significantly upregulated in both PCP treatment alone and in combination with n-TiO2. Chemical analysis and histological examination showed that n-TiO2 adsorb PCP, and n-TiO2 are taken up by developing zebrafish larvae; however, PCP content was not enhanced in the presence of n-TiO2, but the metabolism of PCP to tetrachlorohydroquinone was enhanced in larvae. The results indicate that n-TiO2 enhanced the metabolism of PCP and caused oxidative damage and developmental toxicity, suggesting that NPs can influence the fate and toxicity of associated organic pollutants in the aquatic environment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping