PUBLICATION
Zebrafish Brain Mapping - Standardised Spaces, Length Scales and the Power of N & n
- Authors
- Hunter, P.R., Hendry, A.C., Lowe, A.S.
- ID
- ZDB-PUB-141125-3
- Date
- 2015
- Source
- Developmental Neurobiology 75(6): 557-68 (Review)
- Registered Authors
- Hunter, Paul
- Keywords
- brain mapping, function, neuroimaging, standardised space, zebrafish
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Brain/anatomy & histology*
- Brain/physiology*
- Brain Mapping*/trends
- Gene Expression
- Luminescent Proteins/genetics
- Luminescent Proteins/metabolism
- Neural Pathways/anatomy & histology
- Neural Pathways/physiology
- Neuroimaging
- Zebrafish/anatomy & histology*
- Zebrafish/growth & development
- PubMed
- 25418847 Full text @ Dev. Neurobiol.
Citation
Hunter, P.R., Hendry, A.C., Lowe, A.S. (2015) Zebrafish Brain Mapping - Standardised Spaces, Length Scales and the Power of N & n. Developmental Neurobiology. 75(6):557-68.
Abstract
Mapping anatomical and functional parameters of the zebrafish brain is moving apace. Research communities undertaking such studies are becoming ever larger and more diverse. The unique features, tools and technologies associated with zebrafish are propelling them as the 21(st) century model organism for brain mapping. Uniquely positioned as a vertebrate model system, the zebrafish enables imaging of anatomy and function at different length scales from intra-neuronal compartments to sparsely distributed whole brain patterns. With a variety of diverse and established statistical modelling and analytic methods available from the wider brain mapping communities, the richness of zebrafish neuroimaging data is being realised. The statistical power of population observations (N) within and across many samples (n) projected onto a standardised space will provide vast databases for data-driven biological approaches. This paper reviews key brain mapping initiatives at different levels of scale that highlight the potential of zebrafish brain mapping. By way of introduction to the next wave of brain mappers, an accessible introduction to the key concepts and caveats associated with neuroimaging are outlined and discussed. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping