PUBLICATION
Animal Models of Tuberculosis: Zebrafish
- Authors
- van Leeuwen, L.M., van der Sar, A.M., Bitter, W.
- ID
- ZDB-PUB-141123-3
- Date
- 2014
- Source
- Cold Spring Harbor Perspectives in Medicine 5(3): a018580 (Review)
- Registered Authors
- Bitter, Wilbert, van der Sar, Astrid M.
- Keywords
- none
- MeSH Terms
-
- Animals
- Disease Models, Animal*
- Mycobacterium Infections, Nontuberculous/physiopathology
- Tuberculosis/physiopathology*
- Zebrafish/microbiology*
- PubMed
- 25414379 Full text @ Cold Spring Harb. Perspect. Med.
Citation
van Leeuwen, L.M., van der Sar, A.M., Bitter, W. (2014) Animal Models of Tuberculosis: Zebrafish. Cold Spring Harbor Perspectives in Medicine. 5(3):a018580.
Abstract
Over the past decade the zebrafish (Danio rerio) has become an attractive new vertebrate model organism for studying mycobacterial pathogenesis. The combination of medium-throughput screening and real-time in vivo visualization has allowed new ways to dissect host pathogenic interaction in a vertebrate host. Furthermore, genetic screens on the host and bacterial sides have elucidated new mechanisms involved in the initiation of granuloma formation and the importance of a balanced immune response for control of mycobacterial pathogens. This article will highlight the unique features of the zebrafish-Mycobacterium marinum infection model and its added value for tuberculosis research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping