PUBLICATION
Kidney Injury and Regeneration in Zebrafish
- Authors
- Sander, V., Davidson, A.J.
- ID
- ZDB-PUB-140914-3
- Date
- 2014
- Source
- Seminars in nephrology 34: 437-444 (Review)
- Registered Authors
- Davidson, Alan
- Keywords
- Zebrafish, acute kidney injury, kidney, regeneration, stem cells
- MeSH Terms
-
- Acute Kidney Injury*
- Animals
- Kidney/cytology
- Kidney/physiology*
- Kidney Tubules/cytology
- Kidney Tubules/physiology
- Mesonephros/cytology
- Mesonephros/physiology*
- Nephrons/physiology
- Podocytes/physiology
- Regeneration/physiology*
- Zebrafish
- PubMed
- 25217272 Full text @ Semin. Nephrol.
Citation
Sander, V., Davidson, A.J. (2014) Kidney Injury and Regeneration in Zebrafish. Seminars in nephrology. 34:437-444.
Abstract
Renal tubule epithelial cells can regenerate in response to acute injury. Although this process remains poorly understood, it appears to involve the reactivation of pathways that are operative during embryonic kidney formation. A better understanding of renal regeneration may lead to the development of new therapies that can attenuate acute kidney injury or expedite recovery. The zebrafish is being used as a model to understand renal regeneration. In this review, we summarize the current knowledge on zebrafish kidney formation, describe methods for inducing acute injury, and focus on the unique capacity of the zebrafish adult kidney to undergo de novo nephron formation in response to damage.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping