PUBLICATION
Amyloid precursor protein and neural development
- Authors
- Nicolas, M., Hassan, B.A.
- ID
- ZDB-PUB-140903-16
- Date
- 2014
- Source
- Development (Cambridge, England) 141: 2543-8 (Other)
- Registered Authors
- Keywords
- Amyloid precursor protein, Axonal outgrowth, Neural development, Synapse formation
- MeSH Terms
-
- Alzheimer Disease/genetics*
- Amyloid beta-Protein Precursor/genetics*
- Amyloid beta-Protein Precursor/metabolism*
- Animals
- Caenorhabditis elegans
- Drosophila melanogaster
- Humans
- Mice
- Models, Neurological
- Morphogenesis/physiology*
- Nervous System/growth & development*
- Neurites/physiology
- Neurogenesis/genetics*
- Protein Structure, Tertiary
- Species Specificity
- Synapses/physiology*
- Zebrafish
- PubMed
- 24961795 Full text @ Development
Citation
Nicolas, M., Hassan, B.A. (2014) Amyloid precursor protein and neural development. Development (Cambridge, England). 141:2543-8.
Abstract
Interest in the amyloid precursor protein (APP) has increased in recent years due to its involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and biochemical work has focused on the role of APP in the pathogenesis of this disease. Thus far, however, these studies have failed to deliver successful therapies. This suggests that understanding the basic biology of APP and its physiological role during development might be a crucial missing link for a better comprehension of Alzheimer's disease. Here, we present an overview of some of the key studies performed in various model organisms that have revealed roles for APP at different stages of neuronal development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping