ZFIN ID: ZDB-PUB-140826-8
Function of Sox2 in ependymal cells of lesioned spinal cords in adult zebrafish
Ogai, K., Nakatani, K., Hisano, S., Sugitani, K., Koriyama, Y., Kato, S.
Date: 2014
Source: Neuroscience research   88: 84-7 (Journal)
Registered Authors:
Keywords: Cell proliferation, Sox2, Spinal cord regeneration, Zebrafish
MeSH Terms:
  • Aging
  • Animals
  • Cell Proliferation/physiology
  • Disease Models, Animal
  • Ependyma/metabolism*
  • Motor Neurons/metabolism*
  • Neuroglia/metabolism
  • SOX Transcription Factors/metabolism*
  • Spinal Cord/metabolism
  • Spinal Cord Injuries/metabolism*
  • Spinal Cord Injuries/physiopathology
  • Zebrafish
  • Zebrafish Proteins/metabolism*
PubMed: 25150399 Full text @ Neurosci. Res.
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ABSTRACT
The sex-determining region Y-box 2 (Sox2) is related not only to pluripotency, but also to cell proliferation. Zebrafish can regain their motor function after spinal cord injury (SCI). Following SCI, new motor neurons are produced from proliferating ependymal cells. Here, we investigated the expression and function of Sox2 after SCI in zebrafish. Sox2 was upregulated as early as 1 day post-lesion (dpl) in ependymal cells, which was followed by cell proliferation. Sox2 knockdown significantly decreased the number of proliferating cells at 5 dpl. The results of this study suggest a role of Sox2 as one of the proliferation initiators in ependymal cells after SCI.
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