Yamazoe, S., Liu, Q., McQuade, L.E., Deiters, A., Chen, J.K. (2014) Sequential Gene Silencing Using Wavelength-Selective Caged Morpholino Oligonucleotides. Angewandte Chemie (International ed. in English). 53(38):10114-8.
Spectrally differentiated caged morpholino oligonucleotides (cMOs) and wavelength-selective illumination have been used to sequentially inactivate organismal gene function. The efficacy of these reverse-genetic chemical probes has been demonstrated in zebrafish embryos, and these reagents have been employed to examine the mechanisms of mesoderm patterning.