PUBLICATION
Genes of the adaptive immune system are expressed early in zebrafish larval development following lipopolysaccharide stimulation
- Authors
- Li, F., Zhang, S., Wang, Z., and Li, H.
- ID
- ZDB-PUB-140514-11
- Date
- 2011
- Source
- Chinese Journal of Oceanology and Limnology 29(2): 326-333 (Journal)
- Registered Authors
- Li, Hongyan
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none Full text @ Chin. J. Ocean. Limn.
Citation
Li, F., Zhang, S., Wang, Z., and Li, H. (2011) Genes of the adaptive immune system are expressed early in zebrafish larval development following lipopolysaccharide stimulation. Chinese Journal of Oceanology and Limnology. 29(2):326-333.
Abstract
Information regarding immunocompetence of the adaptive immune system (AIS) in zebrafish Danio rerio remains limited. Here, we stimulated an immune response in fish embryos, larvae and adults using lipopolysaccharide (LPS) and measured the upregulation of a number of AIS-related genes (Rag2, AID, TCRAC, IgLC-1, mIg, sIg, IgZ and DAB) 3 and 18 h later. We found that all of the genes evaluated were strongly induced following LPS stimulation, with most of them responding at 8 d post fertilization. This confirms that a functional adaptive immune response is present in D. rerio larvae, and provides a window for further functional analyses.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping