ZFIN ID: ZDB-PUB-140513-413
Wnt-regulated dynamics of positional information in zebrafish somitogenesis
Bajard, L., Morelli, L.G., Ares, S., Pécréaux, J., Jülicher, F., Oates, A.C.
Date: 2014
Source: Development (Cambridge, England)   141: 1381-91 (Journal)
Registered Authors: Oates, Andrew
Keywords: Embryonic elongation, Fgf signaling, Segmentation clock, Signal gradient, Time-lapse microscopy, Wnt signaling
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Basic Helix-Loop-Helix Transcription Factors/genetics
  • Basic Helix-Loop-Helix Transcription Factors/physiology
  • Body Patterning/genetics
  • Body Patterning/physiology
  • Fibroblast Growth Factors/genetics
  • Fibroblast Growth Factors/physiology
  • Gene Expression Regulation, Developmental
  • Heat-Shock Response/genetics
  • Heat-Shock Response/physiology
  • Intercellular Signaling Peptides and Proteins/genetics
  • Intercellular Signaling Peptides and Proteins/physiology
  • Models, Biological
  • Somites/embryology*
  • Somites/metabolism*
  • T-Box Domain Proteins/genetics
  • T-Box Domain Proteins/physiology
  • Wnt Proteins/antagonists & inhibitors
  • Wnt Proteins/genetics
  • Wnt Proteins/physiology
  • Wnt Signaling Pathway/genetics
  • Wnt Signaling Pathway/physiology*
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism*
  • Zebrafish Proteins/antagonists & inhibitors
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/physiology*
PubMed: 24595291 Full text @ Development
How signaling gradients supply positional information in a field of moving cells is an unsolved question in patterning and morphogenesis. Here, we ask how a Wnt signaling gradient regulates the dynamics of a wavefront of cellular change in a flow of cells during somitogenesis. Using time-controlled perturbations of Wnt signaling in the zebrafish embryo, we changed segment length without altering the rate of somite formation or embryonic elongation. This result implies specific Wnt regulation of the wavefront velocity. The observed Wnt signaling gradient dynamics and timing of downstream events support a model for wavefront regulation in which cell flow plays a dominant role in transporting positional information.