|ZFIN ID: ZDB-PUB-140513-301|
Zebrafish models of cancer: progress and future challenges
Yen, J., White, R.M., Stemple, D.L.
|Source:||Current opinion in genetics & development 24C: 38-45 (Review)|
|Registered Authors:||Stemple, Derek L., White, Richard M.|
|PubMed:||24657535 Full text @ Curr. Opin. Genet. Dev.|
Yen, J., White, R.M., Stemple, D.L. (2014) Zebrafish models of cancer: progress and future challenges. Current opinion in genetics & development. 24C:38-45.
ABSTRACTThe need for scalable strategies to probe the biological consequences of candidate cancer genes has never been more pressing. The zebrafish, with its capacity for high-throughput transgenesis, in vivo imaging and chemical/genetic screening, has ideal features for undertaking this task. Unique biological insights from zebrafish have already led to the identification of novel oncogenic drivers and small molecules being used to treat the human cancer. This review summarizes the recent main findings and describes pertinent areas where the zebrafish can greatly contribute to our understanding of cancer biology and treatment.