|ZFIN ID: ZDB-PUB-140513-109|
The zebrafish as a model of vascular development and disease
Wilkinson, R.N., van Eeden, F.J.
|Source:||Progress in molecular biology and translational science 124: 93-122 (Chapter)|
|Registered Authors:||Wilkinson, Robert|
|Keywords:||Angiogenesis, Blood vessel, Vascular disease, Vasculogenesis, Zebrafish|
|PubMed:||24751428 Full text @ Prog. Mol. Biol. Transl. Sci.|
Wilkinson, R.N., van Eeden, F.J. (2014) The zebrafish as a model of vascular development and disease. Progress in molecular biology and translational science. 124:93-122.
ABSTRACTThe zebrafish has recently emerged as an important animal model to study the formation of the vertebrate vascular network. The small size, optical translucency, and genetic tractability of the zebrafish embryo, in combination with an abundance of fluorescent transgenic lines which permit direct visualization of in vivo vessel formation, have greatly advanced our understanding of vascular biology. Widespread adoption of this powerful system has led to many important discoveries in relation to the mechanisms that underlie blood vessel formation. This review highlights the contribution of the zebrafish system to the current understanding of blood vessel formation and the use of zebrafish to model human vascular disease.
ADDITIONAL INFORMATION No data available