ZFIN ID: ZDB-PUB-140513-109
The zebrafish as a model of vascular development and disease
Wilkinson, R.N., van Eeden, F.J.
Date: 2014
Source: Progress in molecular biology and translational science   124: 93-122 (Chapter)
Registered Authors: Wilkinson, Robert
Keywords: Angiogenesis, Blood vessel, Vascular disease, Vasculogenesis, Zebrafish
MeSH Terms:
  • Animals
  • Blood Vessels/embryology*
  • Blood Vessels/pathology
  • Disease Models, Animal
  • Humans
  • Lymphangiogenesis
  • Muscle Development
  • Vascular Diseases/pathology*
  • Zebrafish/embryology*
  • Zebrafish/physiology*
PubMed: 24751428 Full text @ Prog. Mol. Biol. Transl. Sci.
The zebrafish has recently emerged as an important animal model to study the formation of the vertebrate vascular network. The small size, optical translucency, and genetic tractability of the zebrafish embryo, in combination with an abundance of fluorescent transgenic lines which permit direct visualization of in vivo vessel formation, have greatly advanced our understanding of vascular biology. Widespread adoption of this powerful system has led to many important discoveries in relation to the mechanisms that underlie blood vessel formation. This review highlights the contribution of the zebrafish system to the current understanding of blood vessel formation and the use of zebrafish to model human vascular disease.