ZFIN ID: ZDB-PUB-140509-10
The role of inab in axon morphology of an identified zebrafish motoneuron
Van Ryswyk, L., Simonson, L., and Eisen, J.S.
Date: 2014
Source: PLoS One   9(2): e88631 (Journal)
Registered Authors: Eisen, Judith S.
Keywords: none
MeSH Terms:
  • Animals
  • Axons/physiology*
  • Cell Differentiation
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Green Fluorescent Proteins/metabolism
  • In Situ Hybridization, Fluorescence
  • Interneurons/cytology
  • Motor Neurons/cytology*
  • Neurofilament Proteins/physiology*
  • Oligonucleotide Array Sequence Analysis
  • Spinal Cord/embryology*
  • Spinal Cord/pathology
  • Transcription, Genetic
  • Zebrafish
  • Zebrafish Proteins/physiology*
PubMed: 24533123 Full text @ PLoS One

The ability of an animal to move and to interact with its environment requires that motoneurons correctly innervate specific muscles. Although many genes that regulate motoneuron development have been identified, our understanding of motor axon branching remains incomplete. We used transcriptional expression profiling to identify potential candidate genes involved in development of zebrafish identified motoneurons. Here we focus on inab, an intermediate filament encoding gene dynamically expressed in a subset of motoneurons as well as in an identified interneuron. We show that inab is necessary for proper axon morphology of a specific motoneuron subtype.