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ZIRC
ZFIN ID: ZDB-PUB-140410-26
Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus
Pavlou, S., Astell, K., Kasioulis, I., Gakovic, M., Baldock, R., van Heyningen, V., and Coutinho, P.
Date: 2014
Source: PLoS One   9(1): e87546 (Journal)
Registered Authors: Coutinho, Pedro, van Heyningen, Veronica
Keywords: none
MeSH Terms:
  • Animals
  • Gene Knockdown Techniques
  • Matrix Metalloproteinases, Secreted/genetics
  • Matrix Metalloproteinases, Secreted/metabolism
  • Neurogenesis/physiology*
  • Pineal Gland/cytology
  • Pineal Gland/embryology*
  • SOX Transcription Factors/genetics
  • SOX Transcription Factors/metabolism*
  • Signal Transduction/physiology*
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 24498133 Full text @ PLoS One
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ABSTRACT

The zebrafish epithalamus is part of the diencephalon and encompasses three major components: the pineal, the parapineal and the habenular nuclei. Using sox2 knockdown, we show here that this key transcriptional regulator has pleiotropic effects during the development of these structures. Sox2 negatively regulates pineal neurogenesis. Also, Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling. The correct levels of sox2 are critical for the functionally important asymmetrical positioning of the parapineal organ and for the migration of parapineal cells as a coherent structure. Deviations from this strict control result in defects associated with abnormal habenular laterality, which we have documented and quantified in sox2 morphants.

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