PUBLICATION
A Pyrene Derivative for Hg2+-Selective Fluorescent Sensing and Its Application in In Vivo Imaging
- Authors
- Wang, G.K., Mi, Q.L., Zhao, L.Y., Hu, J.J., Guo, L.E., Zou, X.J., Liu, B., Xie, X.G., Zhang, J.F., Zhao, Q.H., and Zhou, Y.
- ID
- ZDB-PUB-140203-9
- Date
- 2014
- Source
- Chemistry, an Asian journal 9(3): 744-8 (Journal)
- Registered Authors
- Zhang, Junfeng
- Keywords
- fluorescent probes, in vivo imaging, mercury, molecular recognition, sensors
- MeSH Terms
-
- Animals
- Caenorhabditis elegans/anatomy & histology
- Caenorhabditis elegans/chemistry
- Caenorhabditis elegans/metabolism
- Fluorescent Dyes/analysis*
- Fluorescent Dyes/chemical synthesis*
- Fluorescent Dyes/chemistry
- Mercury/analysis*
- Molecular Structure
- Pyrenes/chemical synthesis
- Pyrenes/chemistry*
- Zebrafish/anatomy & histology
- Zebrafish/metabolism
- PubMed
- 24323430 Full text @ Chem. Asian J.
Citation
Wang, G.K., Mi, Q.L., Zhao, L.Y., Hu, J.J., Guo, L.E., Zou, X.J., Liu, B., Xie, X.G., Zhang, J.F., Zhao, Q.H., and Zhou, Y. (2014) A Pyrene Derivative for Hg2+-Selective Fluorescent Sensing and Its Application in In Vivo Imaging. Chemistry, an Asian journal. 9(3):744-8.
Abstract
An Hg2+-selective fluorescent sensor (1) bearing pyrene as a fluorophore was synthesized. A sandwich-stacking binding mode was formed during the binding process, which increased the excimer fluorescence 22-fold at 490nm. Compound 1 was successfully applied in in vivo imaging to trace the enrichment and distribution of mercury in the nervous system, digestive system, and reproductive system of Caenorhabditis elegans, as well as the organs of zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping