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ZIRC
ZFIN ID: ZDB-PUB-131218-10
Znf45l affects primitive hematopoiesis by regulating transforming growth factor-beta signaling
Chen, H., Sun, H., Tao, D., Yang, P., Bian, S., Liu, Y., Zhang, S., and Ma, Y.
Date: 2014
Source: BMB reports 47(1): 21-6 (Journal)
Registered Authors:
Keywords: none
MeSH Terms:
  • Animals
  • Embryo, Nonmammalian/metabolism
  • Embryonic Development
  • Morpholines/metabolism
  • Phosphorylation
  • Protein-Serine-Threonine Kinases/metabolism
  • RNA Interference
  • RNA, Messenger/metabolism
  • Receptors, Transforming Growth Factor beta/metabolism
  • Signal Transduction
  • Transforming Growth Factor beta/metabolism*
  • Zebrafish/growth & development
  • Zebrafish Proteins/antagonists & inhibitors
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 24209630 Full text @ BMB Rep.
FIGURES
ABSTRACT

Znf45l, containing classical C2H2 domains, is a novel member of Zinc finger proteins in zebrafish. In vertebrates, TGF-β signaling plays a critical role in hematopoiesis. Here, we showed that Znf45l is expressed both maternally and zygotically throughout early development. Znf45l-depleted Zebrafish embryos display shorter tails and necrosis with reduced expression of hematopoietic maker genes. Furthermore, we revealed that znf45l locates downstream of TGF-β ligands and maintains normal level of TGF-β receptor typeaphosphorylation. In brief, our results indicate that znf45l affects initial hematopoietic development through regulation of TGF-β signaling.

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