|ZFIN ID: ZDB-PUB-131205-2|
|Source:||Fish Ecotoxicology 86: 337-352 (Chapter)|
|Registered Authors:||Nagel, Roland|
|PubMed:||none Full text @ Fish Ecotoxicology|
In this review, different test systems with fish according to the German Chemicals and Plant Protection Acts are introduced and evaluated. On the basis of a critical consideration of these test systems, the following test concept with zebrafish (Danio rerio) is proposed:
Base level:For ethical reasons,the conventional routine actute toxicity test with juvenile or adult fish should be replaced by a 48 h embryo test with zebrafish.
Level 1: At level 1, the early life-stage test (OECD guideline 210) deserves priority over the prolonged fish test according to OECD guideline 204.
Level 2: Only a complete life-cycle test fulfills the requirements of a chronic toxicity test. It can, therefore, not be substituted by an early life-stage test. Since extrapolation from acute-chronic ratio (ACR) data is not possible as well, there is no alternative to a complete life-cycle test.