ZFIN ID: ZDB-PUB-131205-2
Testing of chemicals with fish - a critical evaluation of tests with special regard to zebrafish
Nagel, R., and Isberner, K.
Date: 1998
Source: Fish Ecotoxicology   86: 337-352 (Chapter)
Registered Authors: Nagel, Roland
Keywords: none
MeSH Terms: none
PubMed: none Full text @ Fish Ecotoxicology
ABSTRACT

In this review, different test systems with fish according to the German Chemicals and Plant Protection Acts are introduced and evaluated. On the basis of a critical consideration of these test systems, the following test concept with zebrafish (Danio rerio) is proposed:

Base level:For ethical reasons,the conventional routine actute toxicity test with juvenile or adult fish should be replaced by a 48 h embryo test with zebrafish.

Level 1: At level 1, the early life-stage test (OECD guideline 210) deserves priority over the prolonged fish test according to OECD guideline 204.

Level 2: Only a complete life-cycle test fulfills the requirements of a chronic toxicity test. It can, therefore, not be substituted by an early life-stage test. Since extrapolation from acute-chronic ratio (ACR) data is not possible as well, there is no alternative to a complete life-cycle test.

ADDITIONAL INFORMATION No data available
ERRATA and NOTES
Review.