PUBLICATION

Testing of chemicals with fish - a critical evaluation of tests with special regard to zebrafish

Authors
Nagel, R., and Isberner, K.
ID
ZDB-PUB-131205-2
Date
1998
Source
Fish Ecotoxicology   86: 337-352 (Chapter)
Registered Authors
Nagel, Roland
Keywords
none
MeSH Terms
none
PubMed
none Full text @ Fish Ecotoxicology
Abstract

In this review, different test systems with fish according to the German Chemicals and Plant Protection Acts are introduced and evaluated. On the basis of a critical consideration of these test systems, the following test concept with zebrafish (Danio rerio) is proposed:

Base level:For ethical reasons,the conventional routine actute toxicity test with juvenile or adult fish should be replaced by a 48 h embryo test with zebrafish.

Level 1: At level 1, the early life-stage test (OECD guideline 210) deserves priority over the prolonged fish test according to OECD guideline 204.

Level 2: Only a complete life-cycle test fulfills the requirements of a chronic toxicity test. It can, therefore, not be substituted by an early life-stage test. Since extrapolation from acute-chronic ratio (ACR) data is not possible as well, there is no alternative to a complete life-cycle test.

Errata / Notes
Review.
Genes / Markers
Probes
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping