PUBLICATION

Hnf1beta and nephron segmentation

Authors
Naylor, R.W., and Davidson, A.J.
ID
ZDB-PUB-131203-22
Date
2014
Source
Pediatric nephrology (Berlin, Germany)   29(4): 659-64 (Review)
Registered Authors
Davidson, Alan, Naylor, Richard
Keywords
none
MeSH Terms
  • Animals
  • Hepatocyte Nuclear Factor 1-beta/metabolism*
  • Hepatocyte Nuclear Factor 1-beta/physiology
  • Humans
  • Nephrons/embryology*
  • Nephrons/metabolism*
  • Organogenesis/physiology
  • Zebrafish Proteins/metabolism*
  • Zebrafish Proteins/physiology
PubMed
24190171 Full text @ Pediatr. Nephrol.
Abstract

The nephron is the functional unit that executes the homeostatic roles of the kidney in vertebrates. Critical to this function is the physical arrangement of the glomerular blood filter attached to a tubular epithelium that is subdivided into specialized proximal and distal segments. During embryogenesis, nephron progenitors undergo a mesenchymal–epithelial transition (MET) and adopt different segment-specific cell fates along the proximo-distal axis of the nephron. The molecular basis of how these segments arise remains largely unknown. Recent studies using the zebrafish have identified the Hnf1beta transcription factor (Hnf1b) as a major regulator of tubular segmentation. In Hnf1b-deficient zebrafish embryos, nephron progenitors fail to adopt the proximo-distal segmentation pattern of the nephron, yet still undergo MET. This observation suggests that the functional segmentation of renal tubular epithelial cells is independent of pathways that induce their epithelialization. Here we review this new role of Hnf1b for nephron segmentation during zebrafish and mouse kidney development.

Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Errata and Notes